Netflix’s documentary Don’t Die: The Man Who Wants to Live Forever follows tech multimillionaire Bryan Johnson’s longevity plan. It is an obsessive quest to reverse aging and embrace immortality. His Blueprint initiative costs over $2 million annually. It includes strict sleep schedules, a mostly vegan diet, 90 daily supplements, LED light therapy, extensive exercise, and frequent medical tests. Johnson, 47, has even undergone blood transfusions from his son and shockwave therapy to optimize his body. His efforts have reportedly reversed his biological age by five years, fueling his goal to reach 150 or beyond.
The science of longevity has gained traction. Researchers like Dan Buettner have identified Blue Zones. These are regions where people live exceptionally long, healthy lives. With global life expectancy rising and the 80+ population expected to hit 426 million by 2050, interest in aging interventions is growing. Beyond general wellness guidelines—like regular exercise and plant-based diets—scientists are exploring deeper strategies to extend lifespan and slow biological aging.
1. Personalized medicine
A shift toward tailored healthcare is emerging, says Dr. Ho See-yunn, chief doctor at Hong Kong’s Restore Integrative Medical Clinic. Instead of a “one-size-fits-all” approach, biological age assessments—including telomere length and genetic tests—help determine individualized strategies. Factors like gut health, stress levels, and hormone balance are analyzed to optimize aging interventions. Personalized medicine also incorporates epigenetics, which explores how lifestyle changes can influence genetic predispositions.
2. Longevity therapeutics
Supplements and medications play a crucial role in cellular health. NMN, a compound popularized by longevity expert David Sinclair, is believed to reverse biological aging, while spermidine has been linked to longer lifespans. Though some anti-aging therapeutics remain unapproved by the FDA, research continues to evolve, with investment in the field increasing.
3. Longevity technology
AI-powered health recommendations and wearable trackers, like Oura rings, offer real-time insights into aging. Clinics such as Chi Longevity in Singapore use cutting-edge equipment to detect cardiovascular risks and assess physical capabilities, helping doctors tailor health plans.
4. Genetic engineering
Advancements in gene therapy, such as CAR-T therapy for leukemia and T-cell reprogramming, offer potential breakthroughs in disease prevention and lifespan extension. Scientists are exploring ways to target aging cells, possibly paving the way for healthier, longer lives.
As Johnson’s extreme longevity journey sparks debate, the broader field of anti-aging science continues to evolve, merging technology, medicine, and lifestyle strategies to redefine human lifespan.
